Product ID:L-METHIONINE, 4500
MSDS Date:04/27/1999
FSC:6505
NIIN:00N092490
Status Code:A
MSDS Number: CJTCH

Emergency Phone: 800-424-9300 (CHEMTREC)

Info Phone: 800-854-3417

Cage: 29089

Telephone: 619-450-5558; 800-854-3417

Cage: 29089

L-METHIONINE

CAS: 63-68-3

RTECS: PD0457000

OSHA PEL N/K

ACGIH TLV: N/K

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL BY INGESTION,
INHALATION OR ABSORPTION THROUGH SKIN. CHRONIC: THERE IS LIMITED
EVIDENCE THAT L-METHIONINE IS MUTAGENIC IN LABORATORY CELL
CULTURES. UNTIL FURTHER TESTING HAS BEEN DONE, IT SHOULD BE
TREATED AS A POSSIBLE MUTAGEN IN HUMANS.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:SKIN: WASH WITH SOAP AND COPIOUS AMOUNTS OF WATER FOR AT
LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES AND WASH
BEFORE WEARING. CONSULT A PHYSICIAN. EYES: FLUSH WITH COPIOUS
AMOUNTS OF WATE R FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING
BY SEPARATING THE EYELIDS WITH FINGERS. CONSULT A PHYSICIAN.
INHALATION: REMOVE TO FRESH AIR AND MONITOR BREATHING. IF BREATHING
BECOMES DIFFICULT, GIVE OXYGEN AND CONSULT A PHYSICIAN. IF
BREATHING STOPS, GIVE ARTIFICIAL RESPIRATION AND CONSULT A
PHYSICIAN. INGESTION: WASH MOUTH OUT WITH WATER AND CONSULT THE
LOCAL POISON CENTER AND A PHYSICIAN.

Extinguishing Media:DRY CHEMICAL POWDER, CARBON DIOXIDE, WATER SPRAY,
ALCOHOL OR POLYMER FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:UPON THERMAL DECOMPOSITION, IT MAY EMIT
TOXIC GASES.

Spill Release Procedures:EVACUATE AREA. WEAR A NIOSH APPROVED
RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS, AND HEAVY RUBBER
GLOVES. SWEEP UP AND PLACE IN A SUITABLE CONTAINER. AVOID RAISING
DUST. HOLD FOR APPROPRIATE DI SPOSAL. WASH SPILL SITE AND VENTILATE
AREA AFTER MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:STORE IN A TIGHTLY CLOSED CONTAINER IN
A COOL, DRY PLACE (+20C). POSSIBLE MUTAGEN. AVOID CONTACT WITH
MATERIAL. AVOID PROLONGED OR REPEATED EXPOSURE. LAB SHOULD BE
EQUIPPED WITH A SAFETY SHOWER AND AN EYE WASH STATION. WASH
THOROUGHLY AFTER HANDLING MATERIAL.
Other Precautions:MATERIAL SHOULD ONLY BE HANDLED BY QUALIFIED,
EXPERIENCED PROFESSIONALS.

Respiratory Protection:USE A NIOSH APPROVED RESPIRATOR.
Ventilation:HANDLE IN A CHEMICAL FUME HOOD WITH ADEQUATE VENTILATION.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EMERGENCY EYEWASH AND DELUGE
SHOWER .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
INGREDIENT INFORMATION: SYNONYM: MET. MOLECULAR WEIGHT: 149.2.
MOLECULAR FORMULA: C*5H*11NO*2S.

Melt/Freeze Pt:>280.C, 536.F
M.P/F.P Text:280C - 282C
Solubility in Water:SOLUBLE
Appearance and Odor:CRYSTALLINE SOLID.

Stability Indicator/Materials to Avoid:YES
AVOID CONTACT WITH STRONG OXIDIZING AGENTS.
Stability Condition to Avoid:STABLE UNDER NORMAL HANDLING PROCEDURES.
Hazardous Decomposition Products:UPON THERMAL DECOMPOSITION, MAY EMIT
TOXIC GASES INCLUDING CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN
OXIDES, AND SULFUR OXIDES.

Waste Disposal Methods:COUNTRY, FEDERAL, STATE, & LOCAL REGULATIONS ARE
VARIED & CHANGE FREQUENTLY. FOR THIS REASON, MANUFACTURER
RECOMMENDS THAT YOU CONTACT YOUR LOCAL DEPARTMENT OF HEALTH
SERVICES FOR INFORMATION ON THE D ISPOSAL OF THIS PRODUCT/ARRANGE
FOR DISPOSAL BY A LICENSED DISPOSAL COMPANY. DISPOSE OF IN
ACCORDANC E WITH LOCAL, STATE, & FEDERAL REGULATIONS .

Toxicological Information:RTECS #: PD0457000. TOXICITY DATA &
REFERENCES: ORL; RAT; LD50: 36 G/KG CHANGE IN MOTOR ACTIVITY;
IMMUNOLOGICAL CHANGES 1983. GIGIENA I SANITARIYA. FOR ENGLISH
TRANSLATION, SEE HYSAAV. 48(6), 20. IPR; RAT; LD50: 4328 MG/KG
DYSPNEA; BODY TEMP DECR 1955. ARCHIVES OF BIOCHEMISTRY &
BIOPHYSICS. 58, 253. IPR; MUS; LD50: >9500 MG/KG 1981. PROGRESS IN
MUTATION RESEARCH. 1, 682. REPRO EFTS & REFERENCES: O RL; RAT;
DOSE: 26100 MG/KG FETOTOXICITY; MUSCULOSKETAL SYS DEVEL ABNORMS
1975. DEUTSCHE TIERAERZTLICHE WOCHENSCHRIFT. 82, 457. ORL; RAT;
DOSE: 14720 MG/KG POST-IMPLANTATION MORTALITY 1975. DEUTSCHE TI
ERAERZTLICHE (OTHER INFO)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:NO INFORMATION AVAILABLE. --TOX INFO: WOCHENSCHRIFT. 82,
457. ORL; RAT; DOSE: 35 G/KG FETOTOXICITY 1992. TERATOLOGY,
INTERNATIONAL JOURNAL OF ABNORM DEVEL. 46, 499. GENETIC DATA &
REFERENCES: OTH; HMN ; DOSE: 2UMOL/L DNA DMG 1982. BIOCHIMICA ET
BIOPHYSICA ACTA. 696, 15. FBR; HMN; DOSE: 125 MG/L UNSCHEDULED DNA
SYNTHESIS 1981. PROGRESS IN MUTATION RESEARCH. 1, 517. IPR; GPG;
DOSE: 500 MG/KG CYTOGEN ETIC ANALYSIS 1970. JOURNAL OF CELL
BIOLOGY. 47, 190A. LYM; HMN; DOSE: 10 MG/L SISTER CHROMATID
EXCHANGE 1996. MUTATION RESEARCH. 372, 75. REVIEWS: TOXICOLOGY
REVIEW REFERENCE 1974. JOURNAL OF AGRICUL TURE & FOOD CHEMISTRY.
22, 2.(SARA REGS)

Transport Information:UN NUMBER: N/A. PROPER SHIPPING NAME: N/A. IATA
CLASS: N/A. IATA PACKING GROUP: N/A.

Federal Regulatory Information:XN. RISK PHRASES: R40: POSSIBLE RISK OF
IRREVERSIBLE EFFECTS. SAFETY PHRASES: S22: DO NOT BREATHE DUST.
S24/25: AVOID CONTACT WITH SKIN AND EYES. S36/37/39: WEAR SUITABLE
PROTECTIVE CLOTHING, GLOVES A ND EYE/FACE PROTECTION. S45: IN CASE
OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY.
State Regulatory Information: